Multiple sclerosis MS is the most common inflammatory disease of the central nervous system in young adults that may lead to progressive disability. Since pharmacological treatments may have substantial side effects, there is a need for complementary treatment options such as specific dietary approaches. Ketone bodies that are produced during fasting diets FDs and ketogenic diets KDs are an alternative and presumably more efficient energy source for the brain. Studies on mice with experimental autoimmune encephalomyelitis showed beneficial effects of KDs and FDs on disease progression, disability, cognition and inflammatory markers. However, clinical evidence on these diets is scarce. In the clinical study protocol presented here, we investigate whether a KD and a FD are superior to a standard diet SD in terms of therapeutic effects and disease progression. This study is a single-center, randomized, controlled, parallel-group study. Secondary endpoints are safety, changes in relapse rate, disability progression, fatigue, depression, cognition, quality of life, changes of gut microbiome as well as markers of inflammation, oxidative stress and autophagy. Safety and feasibility will also be assessed. Preclinical data suggest that a KD and a FD may modulate immunity, reduce disease severity and promote remyelination in the mouse model of MS.
Objectives : Ketogenic diets KDs have long been used to treat epilepsy and are being explored in a variety of diseases. Methods This diet is a single-center, randomized, controlled, parallel-group study. As an athlete I default to cramming in the carbs mostly whole grain but I supplement with sugary sweets, to maintain energy and performance. Keto for the info very interesting. There’s also some evidence that following the diet may help people keto type 2 diabetes lower their blood sugar levels, possibly by encouraging weight loss. Medically reviewed by Daniel Murrell, Diet. But when I asked the doctors for more info, I was handed an informational DVD, can the fast metabolism diet heal gluten intolerance a pamphlet with a number to call on it.
While low-carbohydrate diets like Atkins, Zone, and South Beach may be helpful in losing weight, what role can they play in the health of people with MS? How safe are they? But they also tend to cut healthy high-fiber and vitamin-rich grains, fruits and vegetables. They allow protein and fat-rich foods, like meat, cheese, cream, butter and eggs, in unlimited quantities. The verdict is still out on the long-term safety of low-carb diets. They tend to be high in total fat, especially saturated animal fat, which has been linked to heart disease, cancer, and perhaps even MS. The low-carb craze also restricts fruits, vegetables and whole grains. This can result in deficiencies of valuable vitamins, minerals, phytonutrients, antioxidants and fiber. All of these are important to long-term good health. People with MS need to plan for the long haul. Learn More.