The purpose of this review is to present our current understanding of the genetic etiologies that may cause or predispose to heart failure. We highlight known phenotypes for which a genetic evaluation has clinical utility. The literature continues to demonstrate and confirm a genetic basis for conditions that cause heart failure. Evidence suggests a genetic model involving rare and common variants of strong or weak effect, in combination with environmental factors that may manifest as familial or simplex disease. Clinical genetic testing is available for several phenotypes, which can aid in the diagnosis and identification of at-risk family members. The evaluation of heart failure should include investigating etiologies with a genetic basis. Heart failure, a pan-ethnic disease that is clinically manifest in more than 6. The most common etiologies that underlie heart failure arise from one or more pathological processes directly affecting the ventricular myocardium, termed cardiomyopathies Table 1.
What you may not know is that some cholesterol is needed for good health. Your body actually produces cholesterol. Cholesterol only becomes dangerous when there is too much in your blood. When you have too much cholesterol in your blood, it gets stored in your arteries and can narrow or block these large blood vessels completely. If an artery to your heart is blocked, it causes a heart attack. A blocked artery to the brain causes a stroke. There are a number of reasons why some people have high levels of cholesterol in their blood but it is most often related to diet, exercise and family history. Cholesterol is a type of fat produced by the liver. When you eat foods that are high in fat, your cholesterol level is likely to increase.
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